Freeze Dryer Sisteminin Manifold Donmasını Hızlandırmak İçin Shell Freezing Kullanmalı Mıyız?

Freeze Dryer Sisteminin Manifold Donmasını Hızlandırmak İçin Shell Freezing Kullanmalı Mıyız?

<p><strong>Freeze Dryer Sistemi&rsquo;nizin manifold dondurmasını daha hızlı yapabilmek i&ccedil;in bir y&ouml;ntem arıyorsanız, doğru yazıda buluştuğumuzu s&ouml;yleyebilirim. Bu yazımda, liyofilizasyon sırasında kurutma oranlarını etkileyen temel fakt&ouml;rleri kısaca tartışıyorum. Daha sonra Shell Freezing (Kabin İ&ccedil;i Dondurma) Metodu&rsquo;nun, Bulk Freezing (K&uuml;tlesel Dondurma) Metod&rsquo;una kıyasla size nasıl &ouml;nemli &ouml;l&ccedil;&uuml;de zaman tasarrufu sağlayabileceğini ve bu durumu detaylandırarak birka&ccedil; &ouml;rnek vereceğim.</strong></p> <p><strong>Genel olarak, hacme g&ouml;re y&uuml;zey alanı ne kadar b&uuml;y&uuml;k olursa &uuml;r&uuml;n o kadar hızlı kurur. Daha b&uuml;y&uuml;k bir y&uuml;zey, matristen daha fazla su molek&uuml;l&uuml;n&uuml;n ayrılmasıyla sonu&ccedil;lanır.</strong></p> <p>Ancak burada birka&ccedil; ayrıntıyı daha ifade edeyim. Liyofilizasyon işleminde s&uuml;blimasyon, numunenin y&uuml;zeyinde oluşur. Kurutma işlemi &uuml;r&uuml;n&uuml;n &uuml;st kısmından başlar ve kurutmanın ger&ccedil;ekleştiği yerde bir katman oluşur. Kurutma işlemi sırasında s&uuml;blimasyon, &uuml;r&uuml;n&uuml;n &uuml;st&uuml;nden altına doğru hareket eder. Kurutma, y&ouml;ntemin başında etkilidir ancak s&uuml;blimasyon aşağı doğru hareket ettik&ccedil;e verimlilik azalır. S&uuml;blime su molek&uuml;lleri matristen &ccedil;ıkmadan &ouml;nce, &ldquo;kek&rdquo; olarak da bilinen kurutulmuş &uuml;r&uuml;nden ge&ccedil;meleri gerektiği i&ccedil;in bu s&uuml;re&ccedil; daha zor hale gelir.</p> <p>Belirli bir &uuml;r&uuml;n&uuml;n liyofilizasyon işleminde; kurutma hızı, basın&ccedil; ve sıcaklık gibi &ccedil;eşitli fakt&ouml;rler mevcuttur. &Uuml;r&uuml;n&uuml;n, liyofilize edilen &uuml;r&uuml;n hacmi gibi &ouml;zelliklerinin yanı sıra &uuml;r&uuml;n hazırlanmasının şekli de kurutma oranını etkiler. Daha &ouml;nce de belirtildiği gibi, hacme g&ouml;re &uuml;r&uuml;n&uuml;n y&uuml;zey alanı ne kadar b&uuml;y&uuml;k olursa, kurutma oranı o kadar y&uuml;ksek olur.</p> <p><strong>Bununla birlikte, manifoldun donmasını, kurutmasını ve kurutma verimliliğini artırmanın en iyi yolu Shell Freezing Metodu&rsquo;nu kullanmaktır. Aynı zamanda manifold uygulamalarında, sıvılar 1- 2 cm&#39;den daha kalın bir katmanda şişeler halinde kurutulursa verimlilik daha da artmış olur.</strong></p> <p>Bu uygulama sırasında &uuml;r&uuml;n, soğutma banyosunda rotasyon ile donar. D&ouml;nd&uuml;rme işlemi, &uuml;r&uuml;n&uuml; balon duvarına yayarak y&uuml;zey alanını arttırır ve ince &uuml;r&uuml;n katmanları oluşturulur. Bu, Dewar Aksesuarı bulunan bir Rotary Evaporator ile ger&ccedil;ekleştirilebilir. &Ouml;rneğin, 200 ml suyun 1 L&#39;lik bir balonda dondurulması 4.5 cm&#39;lik bir y&uuml;ksekliğe ulaştırır. Aşağıdaki g&ouml;rselde g&ouml;r&uuml;ld&uuml;ğ&uuml; şekilde, dondurma işlemi sırasında kabı d&ouml;nd&uuml;rerek, donmuş &uuml;r&uuml;n 1 cm&#39;den daha ince eşit ve homojen bir katman &uuml;retmek i&ccedil;in balonun i&ccedil; duvarına yayılır. Bu durum aşağıdaki g&ouml;rselde belirtilmiştir.</p> <p><span style="font-size:11pt"><span style="background-color:white"><span style="font-family:Calibri,sans-serif"><span style="font-size:13.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:white"><img alt="shell freezing, shell frozen flask" 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style="height:335px; width:602px" /></span></span></span></span></span></span></p> <p>&nbsp;</p> <p>Aşağıdaki grafikte deneysel veriler verilmiştir ve benzer manifold freze drying koşullarında, kabin i&ccedil;i donma numunesi (23.9 gsu/balon/saat; turuncu kareler) kullanılarak dondurulduğunda, k&uuml;tlesel dondurmaya (9.9 gsu/balon/saat; mavi noktalar) g&ouml;re s&uuml;blimasyon hızının iki katından fazla olduğunu g&ouml;stermektedir.</p> <p><span style="font-size:11pt"><span style="background-color:white"><span style="font-family:Calibri,sans-serif"><span style="font-size:13.0pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><span style="color:white"><img alt="sublimation, sublimation speed, shell freeze drying" 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0Jcvb7VpP6CYXTwsNXMrSpyE8b5I4xV7w3WUCHAEEEHiJAUoZKHwkmparNwfIx8chI5nZpVzneS4kOFKfsE1rWtDQKAZOoWZoVvAFmOsKLIOupMi4M6VJ6fE7OOtPmuTwxXc8ONewNUkcb53xWWw2Y4ee57QBqCs0omgY8Nu+HsI5iPefmO1FQfRj8o47dDJNE1rBUhy9gtWj/sKMFsbAcoaBx8JxSumYQCQW0ACsAljsrgWEuDzRp5lR98Gou0yU/dYTbt11XCtf1c/UrM0K3gCzHWFFkHXUmRcGdKk9PidnHWrRZmWgNq57XNNWuYaEKz2aOzMLWVNSS5xNSSf3KghbBE2NpJArznKamvvPzHaioPox+UcZyFC12rGvX3Xq5v+1FiNq4A1LRUgZVeebhDaA5a8xCuE3w55IdkGSiDWi7zZBQHqhmaFbwBZjrCiyDrqTIuDOlSenxOzjr9+0Tts8EkrsjQm2m0xywNtDYw2XmF2tWu7Cn5jtRUH0Y/KPcMEJeHmNt6ta9WMzQreALMdYUWQddSZFwZ0qT0+J2cdfv8ACML5rFMxgq6gIGo1Us8dtlsbITW7KJX+G6MhRFQQmxzsaGiRtB4VdtOkbuq7adI3dV206Ru6rtp0jd1XbTpG7qu2nSN3VdtOkbuq7adI3dV206Ru6rtp0jd1XbTpG7qu2nSN3VdtOkbuq7adI3dV206Ru6rtp0jd1XbTpG7qu2nSN3VdtOkbuq7adI3dV206Ru6rtp0jd1XbTpG7qu2nSN3VdtOkbuq7adI3dV206Ru6rtp0jd1XbTpG7qu2nSN3VdtOkbuq7adI3dV206Ru6rtp0jd1XbTpG7qu2nSN3VdtOkbuq7adI3dV206Ru6rtp0jd1XbTpG7qu2nSN3VdtOkbupgkFb7geygp7jM0K3gCzHWFFkHXUmRcGdKk9PidnHX8lzmtBLiABlJTJI5W3o3tc3tBqPkPkjibeke1o7XGgTHskaHMcHDtBqPkskjkBLHtcAaEg1+QSACSaBMkjkbeY9rh2g1+RJLFEKySNYO1xAQcHAFpBByEe+SACSaAJj2SNDmODmnIQahCaEvMYkYXjK2orxszQreALMdYUWQddSZFwZ0qT0+J2cdfybd+u02GF2Y6RzndhuCoTAI+FHsYKNfZw86w6nyHsidRz2tN2pBIyLg5tXWqZgpFJJVg1Chd8i3WljSyzYzYzIKucSBdYuCHQhlqjje2gtDyAO78i2357ZFZgwPaI8QtJo0mtBeVjmD8WIxCJ8TgHNGTnGUfItVfb2ujiE5bCQ6Pu1OVcFhvszqHLK8luS4e778kUcrbkjA5vYVYXuj4GL25WslI2lSxMh4Ls0rGjEZhPB/clx42ZoVvAFmOsKLIOupMi4M6VJ6fE7OOv5Nps4nayji17HBzHdhUFmMcj5ZJL8jgBWlAAP2A+RbbLJamNY2a42tXC7W8oI5owRJKx45roay5T+z8gsY7K0HWFZbKLPjUcDflc/JSl79vkTWYvlZNHJhyNaW1pUEdhCs9mEGI4vL5JHVe75Ellfjvmhmw3PADwW3gaKzWcWdjgHFznPL3uP7uPyLLZRZ7K2AuvgXqmlK3jVN4PdSKN05dDG4FrLvZkBPGzNCt4Asx1hRZB11JkXBnSpPT4nZx19dMzQreALMdYUWQddSZFwZ0qT0+J2cdf3M1oigu373Pko0u/wBEzhCySCrXuIoTW44CgUb2SMa9hq1wBB9zHixsGri+gJo0kCvaVDNHPG2SN1WOyFY8WNg1cH0JFWkA07D9yzNCt4Asx1hRZB11JkXBnSpPT4nZx1/dWB7mcCh7TQtikIRntT+TGMlDTPES80ByNBRmtw9tZ7QK2YXg64KvqL1Cpbe4+ysDjHiQiVzgwvIBVhtEkpmY8lwYRdeWFl4FRdPtfpxf7qzSWmz8FRWhsouM/wCndyi8pen2T05f9vuWZoVvAFmOsKLIOupMi4M6VJ6fE7OOv7qGx4Vh9lxK/oc29TvJtiuusJxOjsLcmdUAI2Or7a7E6Q0DJm0bdRsJDbMY5iyWGMMD6VBH8hQsmaDiyh5/ht1NbKy2zOwnFj2MAcCKC7Vcnf8ADvY8X9s+niqnNlfbYXYTgxjHguJFDep9yzNCt4Asx1hRZB11JkXBnSpPT4nZx19dMzQreALMdYUWQddSZFwb0qT0+vbawNsx7ahRZOunCoULmwyFzgaEU5lylB3X7FylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsXKUHdk2LlKDuybFylB3ZNi5Sg7smxcpQd2TYuUoO7JsTeEbOBQMfsUs8csd1odVMFB12WgrDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMLDCwwsMINA/8ev/xAAmEQACAgEDAgYDAAAAAAAAAAABAgMRABIxUAQhEBMgQWGQFCIw/9oACAECAQE/APsBJyPqI3YKNVnmpHEaFjsMimE2qgQBWUKrI+mSNwwLcw8iR1qNXiurgFTePGHUq3vkUKRXpvvzU0Pn6e9AZEnloFu65qd5xKwQtWAXvzUBn81deuu++Xe2AVzRIGdzvzUwYxMFu86USgvrDe2+AfxrHj0qrXvx5IG5AywRYOdz8DAAPVGhc0MIokE4CAQayR9ZsCuR6mNpQoWrByCMxoA29+gxEIGvfKxWjCMCtnLyzyUnUpG2kg3gOqiNsA9h4Df4yQRhv0Odss8t+EvUMzFiDgFDEfQ174zaiTW/NAkfSZ//xAAlEQABBAICAQQDAQAAAAAAAAABAAIDERIxBFAhEyAiQRAwkGH/2gAIAQMBAT8A/oCApeNJG0uONDuo2GR4aNlSwOgxyIJNqyTak5UkjC0htdwyJ8l4Nuk6NzCQ4UmSGN4c0aUs75scq8d1BN6GXxslSyerIX1V91x2QGFpeG352ia13XIHH9F2GGXjSqtom+6AJXga7qAtErC6qXKMJDMC370ib/TaZJk5za114BOgSiCDRC8D/SiSTZ9z3hgtA2AQEQSCLUbMBRN9jxZWxFxddELkSiSQluq9gkBeW1pWnNkL2kGgqVDso+LJK3JpbSIxsHaJ+z+DpRl5HyC8qh2w5z+O1rQ0EImyntzbWk1uIAvXdEA/xM//2Q==" style="height:335px; width:602px" /></span></span></span></span></span></span></p> <p>&nbsp;</p> <p>&nbsp;</p> <p>Kurutma hızı, genel olarak &uuml;r&uuml;n&uuml;n hacmine g&ouml;re y&uuml;zey alanına bağlıdır. Y&uuml;zey alanı ne kadar b&uuml;y&uuml;k olursa &uuml;r&uuml;n o kadar hızlı kurur, &ccedil;&uuml;nk&uuml; daha fazla su molek&uuml;l&uuml; matristen ayrılabilirler. Manifold donarak kurutmayı kullanırken, &uuml;r&uuml;n y&uuml;zey alanını artırmak i&ccedil;in mutlaka Freeze Drying Metodu&rsquo;nu kullanmayı g&ouml;z &ouml;n&uuml;nde bulundurun. Bu yaklaşımla &uuml;r&uuml;n, donma sırasında balon i&ccedil; duvarına yayılır ve bu da Bulk Freezing Metodu&rsquo;na kıyasla s&uuml;blime oranını artırmaya yardımcı olur.</p> <p>Sistem detayları ve ilgili &uuml;r&uuml;n i&ccedil;in daha detaylı bilgilendirme i&ccedil;in l&uuml;tfen bizlerle iletişime ge&ccedil;iniz.</p>